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Clomid Treatment

How Clomid Works, Why It's Prescribed, and Possible Side Effects

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Updated April 03, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Twins sitting on a bed

About 10% of pregnancies conceived with Clomid will result in twins.

Donnie Ray Jones / flickr

Clomid is the most well-known fertility drug, probably because it is the most commonly used. About 25% of female factor infertility involves a problem with ovulation, which is what Clomid treats.

Clomid is taken as a pill, and not an injection, like stronger fertility drugs. It's also effective, stimulating ovulation 80% of the time.

Clomid may also be marketed under the name Serophene, or you may see it sold under its generic name, clomiphene citrate. In this article, I'll refer to clomiphene citrate by the brand name Clomid, just because that is how most people know the drug.

Note: Clomid is sometimes used as a treatment for male infertility. However, this article focuses on Clomid use in women.

When Is Clomid Used?

If a woman has irregular cycles, or anovulatory cycles (menstruation without ovulation), Clomid may be tried first.

Clomid is used when there are problems with ovulation, but no problems with male infertility or blocked fallopian tubes. (If fallopian tubes are blocked, stimulating ovulation would be pointless -- the egg and sperm can't meet if the tubes are blocked.)

Clomid is often used in the treatment of polycystic ovarian syndrome (PCOS) related infertility. It may also be used in cases of unexplained infertility, or when a couple prefers not to use the more expensive and invasive fertility treatments, like IVF.

Clomid may also be used during an IUI (intrauterine insemination) procedure, but it is rarely used during IVF treatment. With IVF, injectable ovulation meds are more frequently chosen.

How Is Clomid Taken?

You should follow the directions your doctor gives you, as every doctor has a slightly different protocol.

However, the most common dosage of Clomid is 50 mg, taken for five days, on days 3 through 7 of your cycle, or days 5 through 9 of your cycle. (With day one of your cycle being the first day of real menstrual bleeding, and not just spotting.)

Ovulation and pregnancy rates have been shown to be similar whether the drug is started on day two, three, four, or five, so don't feel concerned if your doctor tells you a different protocol to follow than your friend.

If 50 mg doesn't work, your doctor may increase the medication, according to their judgment, for a successive cycle. Or, they may give it another try at 50 mg.

You might think that more is always better, but higher doses, especially at or above 150 mg, can actually make conception more difficult. (See below, under side effects.)

What are Clomid's Common Side Effects?

Clomid's side effects aren't so bad, as far as fertility drugs are concerned. The most common side effects are hot flashes, breast tenderness, mood swings, and nausea. But once the medication is stopped, the side effects will leave, too.

Possible side effects of Clomid include:

  • Enlarged and tender ovaries (14%)
  • Hot flashes (11%)
  • Abdominal tenderness, due to enlarged and tender ovaries (7.4%)
  • Bloating (5.5%)
  • Breast tenderness (2.1%)
  • Vaginal dryness or thicker cervical mucus (percentage of occurrence not available)
  • Nausea and vomiting (2.2%)
  • Anxiety and insomnia (1.9%)
  • Vision disturbances (1.6%)
  • Headache (1.3%)
  • Abnormal uterine bleeding (spotting) (0.5%)
  • Mood swings and fatigue (0.3%)

Read more about Clomid side effects and risks:

The side effect you're probably most familiar with is the risk of multiples. You have a 10% chance of having twins when taking Clomid, but triplets or multiples of more are rare, happening less than 1% of the time.

One of the more annoying side effects to comprehend is that Clomid can decrease the quality of your cervical mucus (which sperm need to make their way to the egg), making conception more difficult.

Clomid can also make the lining of your uterus thinner and less ideal for implantation. This is why "more" is not necessarily better when it comes to Clomid dosage and use.

How Successful Is Clomid?

Clomid will jump start ovulation in 80% of patients, and about 40% to 45% of women using Clomid will get pregnant within six cycles of use.

Using Clomid for more than six cycles is not generally recommended. If six cycles go by, and pregnancy is not achieved, other alternatives may be considered.

More on fertility treatment:

Sources:

Medications for Inducing Ovulation: A Guide for Patients. American Society of Reproductive Medicine. Accessed February 3, 2008. http://asrm.org/uploadedFiles/ASRM_Content/Resources/Patient_Resources/Fact_Sheets_and_Info_Booklets/ovulation_drugs.pdf

Infertility in Women. A.D.A.M. Healthcare Center. Accessed February 3, 2008. http://adam.about.net/reports/000022_7.htm

General Infertility FAQ. InterNational Council on Infertility Information Dissemination, Inc. Accessed February 3, 2008. http://www.inciid.org/faq.php?cat=immunology&id=1

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