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How the Female Reproductive System Really Works

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Updated June 27, 2014

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The Follicular Phase of the Menstrual Cycle
Hormone interaction of FSH, estradiol, LH, and progesterone

When estrogen levels reach a certain point, FSH and LH surge, leading to ovulation.

Speck Made / Wikicommons / CC BY / Altered

During the follicular phase of the menstrual cycle, about five to seven follicles in your ovary (and sometimes both ovaries) start racing towards the finish line.

Their growth is encouraged by the FSH hormone. The name gives it away –- FSH is follicle-stimulating hormone, or in other words, the hormone which stimulates the follicles to grow.

As the follicles grow larger, they begin to release the hormone estrogen. As this estrogen travels through the bloodstream, it makes its way back to the pituitary gland, causing the gland to decrease the FSH production.

This is called negative-feedback – as estrogen rises, FSH lowers.

Eventually, one (and sometimes two) of the follicles become a dominant follicle. The dominant follicle releases an even greater amount of estrogen into the bloodstream.

When the follicle reaches the final stages of maturity, the negative-feedback cycle switches to a positive-feedback cycle. This means that rising estrogen leads to rising FSH.

In other words, the high levels of estrogen suddenly cause a spike in FSH, kind of like a last jolt to the maturing egg.

But after this last FSH sprint, the pituitary gland abruptly slows down the production of FSH.

This is the beginning of the next phase of the menstrual cycle, known as the ovulatory phase.

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  4. Ovulation, Sex for Pregnancy, and Reproduction Basics
  5. Female Reproductive System: FSH and the Follicular Phase

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