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Metformin Treatment for PCOS

Part Two: Side Effects of Metformin

By , About.com Guide

Updated May 23, 2011

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What Are the Side Effects of Metformin?

Metformin's most common side effect is stomach upset, usually diarrhea, but sometimes also vomiting and nausea. Taking metformin in the middle of a meal may help lessen this side effect. This side effect may also lessen over time, and some women find that particular foods trigger more stomach upset than others.

More serious side effects associated with metformin are liver dysfunction and a rare, but extremely serious side effect, lactic acidosis. While taking metformin, your doctor should monitor your kidney and liver functions. People with heart, liver, kidney, or lung disease should not take metformin. Be sure to provide your doctor with a thorough medical history.

The use of metformin to treat infertility related to PCOS is still being researched, and different doctors have opposing views on if, when, and how to use metformin to treat infertility. Don't be afraid to voice your concerns and questions to your care provider, so that together, you can decide if this treatment is for you.

Sources:

Creanga AA, Bradley HM, McCormick C, Witkop CT. "Use of metformin in polycystic ovary syndrome: a meta-analysis." Obstetrics and Gynecology. 2008 Apr;111(4):959-68.

John E. Nestler, M.D. "Metformin in the Treatment of Infertility in PCOS: An Alternative Perspective." Fertility and Sterility. 2008 July; 90(1): 14-16.

Medications for Inducing Ovulation: A Guide for Patients. American Society of Reproductive Medicine. Accessed September 20, 2010. http://asrm.org/uploadedFiles/ASRM_Content/Resources/Patient_Resources/Fact_Sheets_and_Info_Booklets/ovulation_drugs.pdf

Nawaz FH, Rizvi J. "Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome." Gynecologic and Obstetric Investigation. 2010; 69(3):184-9. Epub 2009 Dec 21.

Roy KK, Baruah J, Sharma A, Sharma JB, Kumar S, Kachava G, Karmakar D. "A prospective randomized trial comparing the clinical and endocrinological outcome with rosiglitazone versus laparoscopic ovarian drilling in patients with polycystic ovarian disease resistant to ovulation induction with clomiphene citrate." Archives of Gynecology and Obstetrics. 2010 May; 281(5):939-44. Epub 2009 Dec 3.

Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH. "Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study." Human Reproduction. 2006 Jan; 21(1):80-9. Epub 2005 Sep 30.

Tso LO, Costello MF, Albuquerque LE, Andriolo RB, Freitas V. "Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome." Cochrane Database Systematic Reviews. 2009 Apr 15; (2):CD006105.

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