1. Health
You can opt-out at any time. Please refer to our privacy policy for contact information.

Down Regulation

By

Updated January 12, 2010

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Definition:

Down regulation is sometimes part of IVF treatment, and it involves the use of GnRH antagonists or GnRH agonists to temporarily suppress your body's natural production of FSH and LH. Essentially, your body's reproduction is "shut off" so the doctor can better control the treatment cycle.

After taking the GnRH analogues for a period of days or weeks, ultrasound is used to confirm that the ovaries are not producing eggs and that the uterine lining is thin. Next, fertility drugs meant to stimulate the ovaries are taken.

©2014 About.com. All rights reserved.

We comply with the HONcode standard
for trustworthy health
information: verify here.